ISSCR News


Stem Cells Shed Insight Into Cardiovascular Disease Processes 
Press Release Kym Kilbourne Press Release Kym Kilbourne

Stem Cells Shed Insight Into Cardiovascular Disease Processes 

When thinking about the immune system, most people think about B and T cells and how they can be trained to recognize pathogens, preventing re-infections. Besides this “adaptive” immune system, we also have an “innate” immune system which acts as first line defense against e.g. bacteria and viruses. The textbook view is that the innate immune system is non-specific so that it’s response always follows the same pattern, even for recurring infections. However, research published today in Stem Cell Reports provides evidence that brief exposure to certain “danger signals” can prime the body’s innate immune system into a long-term hyperreactive and inflammatory state termed “trained innate immunity.”

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New Podcast Episode. PSC Developmental Bias: The Mechanism and the Variation in Human Neural Development
Announcements Megan Koch Announcements Megan Koch

New Podcast Episode. PSC Developmental Bias: The Mechanism and the Variation in Human Neural Development

The guests on this episode of The Stem Cell Report studied functional variation in human PSC lines as they progress through neurectoderm versus mesendoderm lineages and fore- versus hind-brain development. They will discuss the origin and consequences of inter-individual variation in the early events orchestrating human neural development, the extent to which such variation might impact on adult health and disease, and how it might be exploited in stem cell therapy. 

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